![]() These include stimulation of gluconeogenesis in hepatocytes, induction of insulin secretion in islet β-cells exposed to fatty acids, and survival of FAO-dependent lymphoma subtypes. Remarkably, the genetic induction of fragmentation phenocopies distinct cell type-specific biological functions of enhanced FAO. Forced mitochondrial elongation following MFN2 over-expression or DRP1 depletion diminishes FAO, while forced fragmentation upon knockdown or knockout of MFN2 augments FAO as evident from respirometry and metabolic tracing. Here, using cellular models representing a wide variety of mitochondrial shapes, we show a strong linear correlation between mitochondrial fragmentation and increased fatty acid oxidation (FAO) rates. Tel: +570 E-mail: Ĭhanges in mitochondrial morphology are associated with nutrient utilization, but the precise causalities and the underlying mechanisms remain unknown. These authors contributed equally to this work 12 Yale-NUS College, University Town, NUS, Singapore.11 Department of Medicine, Harvard Medical School, MA, Boston, USA.10 Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, MA, Boston, USA.9 Molecular Biology Institute of Barcelona, IBMB-CSIC, Barcelona, Spain. ![]() 8 Obesity Research Center, Molecular Medicine, Boston University School of Medicine, MA, Boston, USA.7 Division of Geriatrics and Gerontology, UCSD School of Medicine, CA, La Jolla, USA.6 Department of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon, South Korea.5 Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, MA, Boston, USA.4 Molecular Biology Institute, UCLA, CA, Los Angeles, USA.3 Department of Chemistry & Biochemistry, UCLA, CA, Los Angeles, USA.2 Department of Molecular and Medical Pharmacology, UCLA, CA, Los Angeles, USA.1 Division of Endocrinology, Department of Medicine, David Geffen School of Medicine, Molecular Biology Institute, UCLA, CA, Los Angeles, USA.Two, I have a higher likelihood that the user will choose to engage – that they will click, check out and play our game. I price that into my model because I pay off a download and a click, and then an open,” Oh says. “The presence of the app on the phone can be a plus over time. But unlike other ad inventory, the app continues to be opened over a longer tail making the conversion rate even more compelling over time. Jam City’s Director of Marketing, Sumee Oh, observes that the majority of users typically open their preloaded app within the first 30 days of new device ownership. A Native App Preload strategy mitigates the risk of app abandonment as it allows customers to engage more quickly with the app when they are most actively looking for new content -at the time of device purchase and setup. This success is rooted in Digital Turbine’s capability to dynamically reach users directly on their smartphone at the important stage of device activation as well as over the life of a device. “As an alpha-partner of Digital Turbine, we’ve witnessed impressive results leveraging their Native App Preloads.” “Our goal is to see our games in the hands of new customers, and Digital Turbine provides us an efficient way to do just that,” said Sumee Oh, Jam City’s Director of Marketing. Most of the games Jam City produces are free-to-play and give users the option to make purchases with real money to obtain more lives or add special in-game skills that allow them to advance further in the game faster.Īpp Preloads, an oft overlooked and misunderstood ad unit, are a key driver of their acquisition strategy. Jam City’s user acquisition strategy is integral to their success. ![]() More than 40% of their users are from outside the US. Jam City has fantastic game development skills, but its long-lived success is also due to its ability to reach and retain new users and to grow new geographies as part of their expansion strategy. Jam City’s portfolio of hit gaming apps includes Cookie Jam, Panda Pop, Juice Jam, The Book of Life: Sugar Smash, and Genies & Gems. Their games have been downloaded more than 800 million times and are regularly played each month by nearly 50 million people half of whom live outside the United States. Jam City (formerly SGN Games) is a Los Angeles-based mobile studio behind six of the Top 100 highest grossing games across Google Play and the Apple App Store. ![]()
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